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PROGRAM Microbicides Microbicides are being developed as a female-initiated method for reducing male-to-female transmission of HIV, and possibly other sexually transmitted infections (STIs), when used during sex. A microbicide would most likely be formulated as a vaginal gel, cream, foam, or ring. If proven viable, microbicides will offer a powerful new prevention tool in the fight against AIDS.
The Population Council has worked for nearly two decades to develop safe and effective vaginal microbicides. The Phase 3 clinical trial of the Population Council’s candidate microbicide Carraguard® did not demonstrate that Carraguard is effective in preventing male-to-female HIV transmission during vaginal intercourse. Carraguard was shown to be safe for use during vaginal sex over a two-year period. This finding is important because Carraguard is an ingredient of next-generation microbicide candidates being developed at the Council. Several of these candidates combine Carraguard with one or more ingredients that have been shown to be effective in preventing virus transmission in laboratory settings. Carraguard is the first candidate microbicide to have completed a Phase 3 trial without any safety concerns. (news release) Why Microbicides? (continued) The following pages provide additional information on the Council's microbicides program: Nonclinical Laboratory Studies
Behavioral and Social Science Research History of Research, 1989–Present See Also
Contact: microbicide@popcouncil.org Carraguard® is the Population Council's US trademark for pharmaceutical preparations, namely microbicides, for use in preventing infection.
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